Byoungkoo Lee


I’m a computational biologist and postdoctoral fellow at the Center for Quantitative Medicine at UConn Health, working with Dr. Reinhard Laubenbacher. How the biological system orchestrates and regulates its intracellular and extracellular reactions from molecular level to whole organism level is my ongong research question. Currently, how fungal spores in the lung initiate invasive aspergillosis disease, how our immune system responses to them, and which conditions in immunocompromised patients can make the disease worse are very important questions and want to contribute to more comprehensively understanding the invasive aspergillosis disease using a multiscale modeling and simulation for massive different parameter conditions.


Ph.D., Computational Biology, Carnegie Mellon University, 2009.

M.S., Electronic Engineering, Konkuk University, Seoul, South Korea, 1998.

B.S., Electronic Engineering, Konkuk University, Seoul, South Korea, 1996.


1998-2000       Research Engineer, KNC, South Korea

2000-2004      Software Engineer, Willtech, South Korea

2009-2011        Postdoctoral research associate, Carnegie Mellon University, Pittsburgh, PA

2011-2015        Postdoctoral fellow, Georgia State University, Atlanta, GA

2016-                Postdoctoral fellow, UConn Health, Farmington, CT


  1. J. Konen, S. Wilkinson, B. Lee, H. Fu, W. Zhou, Y. Jiang, and A. I. Marcus. LKB1 kinase-dependent and –independent defects

disrupt polarity and adhesion signaling to drive collagen remodeling during invasion, Mol. Biol. Cell, 2016.

  1. B. Lee, X. Zhou, K. Riching, K. W. Eliceiri, P. J. Keely, S. A. Guelcher, A. Weaver, Y. Jiang, A three-dimensional computational

model of collagen network mechanics, PLoS ONE, 2014.

  1. G. R. Smith, L. Xie, B. Lee, R. Schwartz, Applying molecular crowding models to simulations of virus capsid assembly in vitro,

Biophysical Journal, 106, 310, 2014.

  1. 4. B. Lee, P. R. LeDuc, and R. Schwartz, Three-dimensional stochastic off-lattice model of binding chemistry in crowded

environments, PLoS ONE, 7, e30131, 2012.

  1. B. Lee, P. R. LeDuc, and R. Schwartz, Unified regression model of binding equilibria in crowded environments, Scientific Reports,

1, 97, 2011.

  1. B. Lee, P. R. LeDuc, and R. Schwartz, Parameter effects on binding chemistry in crowded media using a two-dimensional

stochastic off-lattice model, Physical Review E, 80, 041918, 2009

  1. B. Lee, P. R. LeDuc, and R. Schwartz, Stochastic off-lattice modeling of molecular self-assembly in crowded environments by

Green’s function reaction dynamics, Physical Review E, 78, 031911, 2008

Book chapter

  1. He, B. Lee, and Y. Jiang. Systems Biology of Tumor Microenvironment: Quantitative Modeling and Simulations, Springer,

 Chapter IV, 2016.  ISBN 978-3-319-42023-3